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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) of greater than 27, given that they also suffer from weight-related medical issues such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder and as an aid to stop smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie eating and working out, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical exercise. Results from a clinical trial that enrolled patients without diabetes demonstrated that patients had an average weight loss of four years old.1% instead of participants who were given placebos) throughout a 12- month period, while another study involving patients with type 2 diabetes had an average weight loss of 2% over treatment with placebo at 12 months.
Using two separate drugs to lose weight naturally can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the people who go through it you need to err on the side of caution and let the FDA do its job and demand some investigation be done so your public knows the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies come in business to generate money and that they would say anything to keep people on the medications.
Researchers discovered that participants taking this drug for any year, lost weight within 4 weeks and have kept the load off throughout the 56 weeks in the study. Contrave can be a combination in the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which can be made up of multiple active ingredient, which may make them far better and safer.
Combo-pilling could be the newest fad or also the newest ahead under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular is the fact that at the time of right now there aren't any long term prescription diet pills that have been approved by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be authorized by the FDA.
Seizures can be a side effect with Contrave and must not be taken in people with seizure disorders. The drug could also raise blood pressure level and pulse rate, and must not be used in those with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.
The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must not used in patients with uncontrolled high hypertension, and also by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.
New UCLA study on smokers with mental, drug, and alcohol problems