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Evidence is increasing that all addiction without exception is related to difficulty with the brain's reward center, especially the mesolimbic system. This section of the problem regulates reward responses in establishing food and sex, plus nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both when they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to shed weight can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it one should err along the side of caution and let the FDA do its job and demand some research be done so the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies are in business to make money and that they would say everything to keep people on his or her medications.
Researchers found out that participants investing in this drug for a year, dropped a few pounds within four weeks and have kept the load off through the entire 56 weeks of the study. Contrave is a combination with the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which are made up of several active ingredient, which might make them more efficient and safer.
Combo-pilling is the newest fad or better yet the newest in the future under scrutiny and so it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular could be the fact that as of right now there aren't any long term prescription weight loss supplements that have been approved by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be approved by the FDA.
Seizures can be a side effect with Contrave and really should not be taken in those with seizure disorders. The drug could also raise blood pressure level and heartrate, and shouldn't be used in those with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug.
The FDA also warned that Contrave can raise hypertension and pulse rate and must not be used in patients with uncontrolled high blood pressure, as well as by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients on the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking.
Other people who should avoid using Contrave are patients suffering from bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave really should not be prescribed for females who are pregnant or looking to become pregnant.